Primary treatment of malignant retinal detachment caused by choroidal breast cancer metastasis using only systemic chemotherapy and anti-HER-2 therapy

Introduction: Choroidal metastasis is a disabling complication of several types common cancer, including breast cancer. Metastases to the choroid may present insidiously but ultimately cause significant visual disturbance and more rarely result in retinal detachment, causing sudden profound impairment. The usual treatment choice for choroidal metastases palliative radiotherapy. External beam radiotherapy posterior orbit often effective stabilizing improving symptoms it can usually be given only once carries risk cataract induction as side effect. Case Report: Here we report using systemic therapy [chemotherapy initial dual anti-human epidermal growth factor receptor-2 (HER-2) therapy] treat 69-year-old female presenting with newly diagnosed widespread secondary major symptom which was related exudative detachment caused by metastases. treated effectively allowed improve quickly, positive effect anti-cancer could observed directly serial ophthalmological examination over first two months cancer treatment, allowing earlier detection response than would normally seen on routine radiological scanning. Conclusion: We propose that selected cases alone sufficient from cancers are expected show marked relatively rapid therapy, such HER-2-positive kept reserve further malignant lesions future.